Wait, are you talking about Clear or Sprint now? Regardless, handoffs between band 41 and any other FDD band will be hard due to the nature of the beast, but it shouldn't be a big deal.
No harder than handoff between FDD bands, i.e. bad. I am very displeased with the single radio path Sprint is taking with their new devices. Korea and Japan are showing off 2-3 band LTE-A carrier aggregation and we are cutting radios out of handsets. Sweet life, Sprint.